BDBM461665 US10774071, Example B-132

SMILES COc1nc(O[C@H]2CCc3c2cccc3-c2cccc(c2Cl)-c2cc(C)c(CN3C[C@@H]4C[C@@]4(C3)C(O)=O)c(OC)n2)c(Cl)cc1CNC[C@@H]1CCC(=O)N1

InChI Key InChIKey=XLOZTTMZUKQFNB-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 461665   

LigandPNGBDBM461665(US10774071, Example B-132)
Affinity DataIC50: 0.266nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

LigandPNGBDBM461665(US10774071, Example B-132)
Affinity DataEC50:  57nMAssay Description:Compounds were tested in a functional co-culture reporter assay in which TCR-mediated NFAT activity is inhibited by the engagement of PD-1 with PD-L1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent