BDBM463384 US10781181, Example 62::ethyl 3-[(3-amino-4-{[2-(3-chlorophenoxy)ethyl]carbamoyl}pyrazol-1-

SMILES CCOC(=O)c1cccc(Cn2cc(C(=O)NCCOc3cccc(Cl)c3)c(N)n2)c1

InChI Key InChIKey=KPRMEECKXIGZBV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463384   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463384(ethyl 3-[(3-amino-4-{[2-(3-chlorophenoxy)ethyl]car...)
Affinity DataIC50: 7.15E+3nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463384(ethyl 3-[(3-amino-4-{[2-(3-chlorophenoxy)ethyl]car...)
Affinity DataIC50: 4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25° C. with the fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
Go to US Patent