BDBM464007 US10781211, Example 238::US10781211, Example 275

SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2Cc2ccc(cc2CN2CCCCC2)C(F)(F)F)CC1)C(F)(F)F

InChI Key InChIKey=PLYMVFMZSNEEIB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 464007   

TargetMonoglyceride lipase(Mouse)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM464007(US10781211, Example 275 | US10781211, Example 238)
Affinity DataIC50: 550nMAssay Description:MAGL, ABHD6 and FAAH: Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
US Patent

TargetFatty-acid amide hydrolase 1(Mouse)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM464007(US10781211, Example 275 | US10781211, Example 238)
Affinity DataIC50: 1.00E+3nMAssay Description:MAGL, ABHD6 and FAAH: Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
US Patent

TargetMonoacylglycerol lipase ABHD6(Mouse)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM464007(US10781211, Example 275 | US10781211, Example 238)
Affinity DataIC50: 1.00E+3nMAssay Description:MAGL, ABHD6 and FAAH: Proteomes (mouse brain membrane fraction or cell lysates) (50 μL, 1.0 mg/mL total protein concentration) were preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM464007(US10781211, Example 275 | US10781211, Example 238)
Affinity DataIC50: 100nMAssay Description:Human: Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM464007(US10781211, Example 275 | US10781211, Example 238)
Affinity DataIC50: 100nMAssay Description:Human: Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0-2.0 mg/mL total protein concentration) were preincubated with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
US Patent