BDBM464317 3-(5-(1H-pyrazol-4- yl)pyridin-2-yl)-8-(2- hydroxy-2- methylpropanoyl)-1- (3-methoxybenzyl)- 1,3,8- triazaspiro[4.5]decan- 2-one::US10787450, Example 199

SMILES COc1cccc(CN2C(=O)N(CC22CCN(CC2)C(=O)C(C)(C)O)c2ccc(cn2)-c2cn[nH]c2)c1

InChI Key InChIKey=SZXGGIIUDMHFQE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464317   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464317(3-(5-(1H-pyrazol-4- yl)pyridin-2-yl)-8-(2- hydroxy...)
Affinity DataIC50: 16nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent