BDBM464572 Preparation of N-((4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl)-1-(isopropylsulfonyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)dihydroindole-4-carboxamide ::US10793549, Compound G-47

SMILES Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(N4CCN(C)CC4)nc3)cc3c2CCN3S(=O)(=O)C(C)C)c(=O)[nH]1

InChI Key InChIKey=MRSABGAGWFPBGX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464572   

TargetHistone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 464572BDBM464572(N-((4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)m...)
Affinity DataIC50: 160nMAssay Description:Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent