BDBM469360 US10807986, Example 11::US11046696, Compound 11

SMILES CCCCC(C)n1nc(C(=O)Nc2ccc(COC)cc2)c2c(N)ncnc12

InChI Key InChIKey=WEARTKFHIQUSER-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 469360   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM469360(US10807986, Example 11 | US11046696, Compound 11)
Affinity DataIC50: 3.80nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM469360(US10807986, Example 11 | US11046696, Compound 11)
Affinity DataIC50: 6.60nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET (V804L or V804M) (i.e., RET with V804L or V804M mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM469360(US10807986, Example 11 | US11046696, Compound 11)
Affinity DataIC50: 3.80nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM469360(US10807986, Example 11 | US11046696, Compound 11)
Affinity DataIC50: 6.60nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent