BDBM470890 (1S,3'R,6'R,7'S,8'E,11'S,12'R)- 6-chloro-7'-methoxy-11',12'- dimethyl-7'-((4-((3R)- tetrahydro-3-furanyl)-1- piperazinyl)methyl)-3,4- dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 15'-one 13',13'-dioxide::US10821115, Example 275

SMILES CO[C@@]1(CN2CCN(CC2)C2CCOC2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=NBRIPEAEMYKKLU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 470890   

LigandPNGBDBM470890(US10821115, Example 275 | (1S,3'R,6'R,7'S,8'E,11'S...)
Affinity DataIC50: 0.176nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
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Date in BDB:
6/20/2021
Entry Details
US Patent