BDBM47167 CHEMBL201511::US8957103, Z1::US9364459, A

SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12

InChI Key InChIKey=CZGMEOAMQWAJOY-UHFFFAOYSA-N

Data  61 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 61 hits for monomerid = 47167   

TargetVascular endothelial growth factor receptor 2(Human)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 5nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 5nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Johannes Gutenberg University of Mainz

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 18nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 22nMAssay Description:Inhibition of VEGFR3 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 26nMAssay Description:Inhibition of VEGFR2 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 55nMAssay Description:Inhibition of VEGFR1 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 70nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johannes Gutenberg University of Mainz

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 71nMAssay Description:Inhibition of GSK3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 90nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 90nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Johannes Gutenberg University of Mainz

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 166nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Johannes Gutenberg University of Mainz

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 270nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Johannes Gutenberg University of Mainz

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 650nMAssay Description:Inhibition of human recombinant FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 680nMAssay Description:Inhibition of human recombinant PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 680nMAssay Description:Inhibition of human PDGFR betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 740nMAssay Description:Inhibition of human recombinant TIE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 943nMAssay Description:Inhibition of PDGFRalpha after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 970nMAssay Description:Inhibition of human FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 990nMAssay Description:Inhibition of human recombinant SAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johannes Gutenberg University of Mainz

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.00E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Johannes Gutenberg University of Mainz

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human GSK3 betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Johannes Gutenberg University of Mainz

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.10E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of PDGFRbeta after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of KIT after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 2.63E+3nMAssay Description:Inhibition of TIE2 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human TIE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human recombinant EPHB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of human recombinant Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human recombinant CDK2/cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 6.97E+3nMAssay Description:Inhibition of IGF1R after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of human CDK2 (with cyclin A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of human IGF1-RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of human CDK4 (with cyclin D1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of human Aurora-AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of EGFR after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human recombinant IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of ERBB2 after 80 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human recombinant CDK4/cyclin D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hadassah Hebrew University Hospital

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human EPHB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human recombinant INS-RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human recombinant Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Eberhard-Karls University

Curated by ChEMBL
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human recombinant SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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