BDBM472208 (1R,3S,5R)-2-(2- (3-acetyl-5-(2- methylpyrimidin- 5-yl)-1H-indazol- 1-yl)acetyl)-N-(2- fluoro-3- methylbut-2-en-1- yl)-2-azabicyclo[3.1.0] hexane-3-carboxamide::US10822352, Comp No. 482

SMILES [#6]\[#6](-[#6])=[#6](/F)-[#6]-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6@H]-2-[#6]-[#6@H]-2-[#7]-1-[#6](=O)-[#6]-n1cc(-[#6](-[#6])=O)c2cc(ccc12)-c1cnc(-[#6])nc1

InChI Key InChIKey=PXDIBIQWOJOIGY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 472208   

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM472208(US10822352, Comp No. 482 | (1R,3S,5R)-2-(2- (3-ace...)
Affinity DataIC50: 1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent