BDBM476351 2-chlorophenyl (3S)-4-{3-cyclohexyl- N-[4-(5-hydroxy-1,3,4-oxadiazol-2- yl)cyclohexyl]-D-alanyl}-3- [(thiophen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 7

SMILES O=C(NCc1cccs1)[C@@H]1CN(C(=O)Oc2ccccc2Cl)CCN1C(=O)[C@@H](CC1CCCCC1)NC1CCC(c2nnc(O)o2)CC1

InChI Key InChIKey=HNCMLOBFDLGECC-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476351   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476351BDBM476351(2-chlorophenyl (3S)-4-{3-cyclohexyl- N-[4-(5-hydro...)
Affinity DataIC50: 24.4nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
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Date in BDB:
7/25/2021
Entry Details
US Patent