BDBM476355 2-chlorophenyl (3S)-4-{3-cyclohexyl- N-[4-(hydorxymethyl)-4- methylcyclohexyl]-D-alanyl}-3- [(thiophen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 11

SMILES CC1(CO)CCC(N[C@H](CC2CCCCC2)C(=O)N2CCN(C(=O)Oc3ccccc3Cl)C[C@H]2C(=O)NCc2cccs2)CC1

InChI Key InChIKey=YBMQAWJYJBVHLV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476355   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476355BDBM476355(2-chlorophenyl (3S)-4-{3-cyclohexyl- N-[4-(hydorxy...)
Affinity DataIC50: 23.3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent