BDBM476360 US10875851, Example 16::naphthalen-1-yl (3S)-4-[N2-(2-benzyl- 2-azaspiro[4.5]dec-8-yl)-D-lysyl]-3- [(thiophen-2- ylmethyl)carbamoyl]pipreazine-1- carboxylate

SMILES NCCCC[C@@H](NC1CCC2(CC1)CCN(Cc1ccccc1)C2)C(=O)N1CCN(C(=O)Oc2cccc3ccccc23)C[C@H]1C(=O)NCc1cccs1

InChI Key InChIKey=KEZATGHLZBKHDR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476360   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476360BDBM476360(naphthalen-1-yl (3S)-4-[N2-(2-benzyl- 2-azaspiro[4...)
Affinity DataIC50: 11.8nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent