BDBM476387 1-oxo-1,2,3,4-tetrahydroisoquinolin-5- yl (3S)-4-(N,3-dicyclohexyl-D- alanyl)-3-[(thiophpen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 43

SMILES O=C(NCc1cccs1)[C@@H]1CN(CCN1C(=O)[C@@H](CC1CCCCC1)NC1CCCCC1)C(=O)Oc1cccc2C(=O)NCCc12

InChI Key InChIKey=WMIGMVNLLKETKJ-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476387   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476387BDBM476387(1-oxo-1,2,3,4-tetrahydroisoquinolin-5- yl (3S)-4-(...)
Affinity DataIC50: 20.2nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent