BDBM476397 2-chlorophenyl (3S)-4-{N-cyclohexyl- 3-[1-(methylsulfonyl)piperidin-4-yl]- D-alanyl}-3-[(thiophen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 53

SMILES CS(=O)(=O)N1CCC(C[C@@H](NC2CCCCC2)C(=O)N2CCN(C[C@H]2C(=O)NCc2cccs2)C(=O)Oc2ccccc2Cl)CC1

InChI Key InChIKey=YHMWESPPLQHLNK-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476397   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476397BDBM476397(2-chlorophenyl (3S)-4-{N-cyclohexyl- 3-[1-(methyls...)
Affinity DataIC50: 19.7nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
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Date in BDB:
7/25/2021
Entry Details
US Patent