BDBM476427 1-chloronaphthalen-2-yl (3S)-3-{[4- (aminomethyl)-3- methoxybenzyl]carbamoyl}-4-[N6- (methylsulfonyl)-D-lysyl]piperazine- 1-carboxylate::US10875851, Example 83

SMILES COc1cc(CNC(=O)[C@@H]2CN(CCN2C(=O)[C@H](N)CCCCNS(C)(=O)=O)C(=O)Oc2ccc3ccccc3c2Cl)ccc1CN

InChI Key InChIKey=ZEIKWJRGTXJYRU-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476427   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476427BDBM476427(1-chloronaphthalen-2-yl (3S)-3-{[4- (aminomethyl)-...)
Affinity DataIC50: 28.4nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent