BDBM476473 (2S)-1-[N2-(2-benzyl-2- azaspiro[4.5]dec-8-yl)-D-lysyl]-4- [(4S,5S)-4-methyl-5-phenyl-4,5- dihydro-1,3-oxazol-2-yl]-N-(thiophen- 2-ylmethyl)piperazine-2-carboxamide::US10875851, Example 129

SMILES C[C@@H]1N=C(N2CCN(C(=O)[C@@H](CCCCN)NC3CCC4(CC3)CCN(Cc3ccccc3)C4)[C@H](C(=O)NCc3cccs3)C2)O[C@H]1c1ccccc1

InChI Key InChIKey=RDMBQDKRBSXIJH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476473   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476473BDBM476473((2S)-1-[N2-(2-benzyl-2- azaspiro[4.5]dec-8-yl)-D-l...)
Affinity DataIC50: 13nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent