BDBM476478 (2S)-1-[N2-cyclohexyl-N6- (methylsulfonyl)-D-lysyl]-4-[(4S,5S)- 4-methyl-5-(3-methylphenyl)-4,5- dihydro-1,3-oxazol-2-yl]-N-(thiophen- 2-ylmethyl)piperazine-2-carboxamide::US10875851, Example 134

SMILES Cc1cccc([C@@H]2OC(N3CCN(C(=O)[C@@H](CCCCNS(C)(=O)=O)NC4CCCCC4)[C@H](C(=O)NCc4cccs4)C3)=N[C@H]2C)c1

InChI Key InChIKey=NARKSXVJTMZWAN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476478   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476478BDBM476478((2S)-1-[N2-cyclohexyl-N6- (methylsulfonyl)-D-lysyl...)
Affinity DataIC50: 10.3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent