BDBM476481 (2S)-1-(N,3-dicyclohexyl-D-alanyl)-4- (4,4-dimethyl-5-phenyl-4,5-dihydro- 1,3-oxazol-2-yl)-N-(thiophen-2- ylmethyl)piperazine-2-carboxamide::US10875851, Example 137::US10875851, Example 140

SMILES CC1(C)N=C(N2CCN(C(=O)[C@@H](CC3CCCCC3)NC3CCCCC3)[C@H](C(=O)NCc3cccs3)C2)OC1c1ccccc1

InChI Key InChIKey=UTABTEKQFBFYOL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 476481   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476481BDBM476481(US10875851, Example 140 | (2S)-1-(N,3-dicyclohexyl...)
Affinity DataIC50: 19nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476481BDBM476481(US10875851, Example 140 | (2S)-1-(N,3-dicyclohexyl...)
Affinity DataIC50: 23.2nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent