BDBM476491 (2S)-4-(4,4-dimethyl-5-phenyl-4,5- dihydro-1,3-oxazol-2-yl)-1- (N2,N2,N6,N6-tetramethyl-D-lysyl)-N- (thieno[3,2-c]pyridin-2- ylmethyl)piperazine-2-carboxamide::US10875851, Example 147

SMILES CN(C)CCCC[C@H](C(=O)N1CCN(C2=NC(C)(C)C(c3ccccc3)O2)C[C@H]1C(=O)NCc1cc2cnccc2s1)N(C)C

InChI Key InChIKey=UKNOTOYGBXTHEK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476491   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476491BDBM476491((2S)-4-(4,4-dimethyl-5-phenyl-4,5- dihydro-1,3-oxa...)
Affinity DataIC50: 44.1nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent