BDBM476519 (2S)-N-(3-chlorobenzyl)-1-[N-(1- methylethyl)-6-piperidin-1-yl-D- norleucyl]-4-[(4S,5S)-4-methyl-5- phenyl-4,5-dihydro-1,3-oxazol-2- yl]piperazine-2-carboxamide::US10875851, Example 175

SMILES CC(C)N[C@H](CCCCN1CCCCC1)C(=O)N1CCN(C2=N[C@@H](C)[C@H](c3ccccc3)O2)C[C@H]1C(=O)NCc1cccc(Cl)c1

InChI Key InChIKey=JDMGVKMELSKODE-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476519   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476519BDBM476519((2S)-N-(3-chlorobenzyl)-1-[N-(1- methylethyl)-6-pi...)
Affinity DataIC50: 6.60nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent