BDBM476521 (2S)-1-{N-[4- (aminomethyl)cyclohexyl]-6- piperidin-1-yl-D-norleucyl}-N-[(5- carbamoylthiophen-2-yl)methyl]-4- [(4S,5S)-4-methyl-5-phenyl-4,5- dihydro-1,3-oxazol-2-yl]piperazine-2- carboxamide::US10875851, Example 177

SMILES C[C@@H]1N=C(N2CCN(C(=O)[C@@H](CCCCN3CCCCC3)NC3CCC(CN)CC3)[C@H](C(=O)NCc3ccc(C(N)=O)s3)C2)O[C@H]1c1ccccc1

InChI Key InChIKey=RUBFNAJTZIWJLV-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476521   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476521BDBM476521((2S)-1-{N-[4- (aminomethyl)cyclohexyl]-6- piperidi...)
Affinity DataIC50: 27.9nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent