BDBM476526 (2S)-1-{N-(4-carbamoylcyclohexyl)-3- [1-(4-carbamoylcyclohexyl)piperidin- 4-yl]-D-alanyl}-4-[(4S,5S)-4-methyl- 5-phenyl-4,5-dihydro-1,3-oxazol-2- yl]-N-(thiophen-2- ylmethyl)piperazine-2-carboxamide::US10875851, Example 182

SMILES C[C@@H]1N=C(N2CCN(C(=O)[C@@H](CC3CCN(C4CCC(C(N)=O)CC4)CC3)NC3CCC(C(N)=O)CC3)[C@H](C(=O)NCc3cccs3)C2)O[C@H]1c1ccccc1

InChI Key InChIKey=WTGQRTVTXOGYCB-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476526   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476526BDBM476526((2S)-1-{N-(4-carbamoylcyclohexyl)-3- [1-(4-carbamo...)
Affinity DataIC50: 34.2nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent