BDBM477681 US10889571, Example 22::US20240101536, Example 22

SMILES CC(C)n1cnc2cc(cc(-c3cscn3)c12)C(=O)Nc1ccc(OC(F)(F)Cl)cc1

InChI Key InChIKey=NIOLDGWHUZUZPQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477681   

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns Pharmaceuticals

US Patent
LigandPNGBDBM477681(US10889571, Example 22 | US20240101536, Example 22)
Affinity DataIC50: 0.310nMAssay Description:The activity of the enzyme and compound inhibition was tested using an EZ reader microfluidic mobility shift assay (PerkinElmer, Waltham, MA). For in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
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TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns Pharmaceuticals

US Patent
LigandPNGBDBM477681(US10889571, Example 22 | US20240101536, Example 22)
Affinity DataIC50: 0.310nMAssay Description:ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent