BDBM477697 US10889571, Example 38::US20240101536, Example 38

SMILES O[C@@H]1CCCn2c1nc1cc(cc(-c3ccn[nH]3)c21)C(=O)Nc1ccc(OC(F)(F)Cl)cc1

InChI Key InChIKey=RQGWLSGIZDXUSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477697   

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns

US Patent
LigandPNGBDBM477697(US10889571, Example 38 | US20240101536, Example 38)
Affinity DataIC50: 0.630nMAssay Description:ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns

US Patent
LigandPNGBDBM477697(US10889571, Example 38 | US20240101536, Example 38)
Affinity DataIC50: 0.630nMAssay Description:The activity of the enzyme and compound inhibition was tested using an EZ reader microfluidic mobility shift assay (PerkinElmer, Waltham, MA). For in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent