BDBM477702 US10889571, Example 43::US20240101536, Example 43

SMILES O[C@H]1CCc2nc3cc(cc(-c4cncnc4)c3n2C1)C(=O)Nc1ccc(OC(F)(F)Cl)cc1

InChI Key InChIKey=QHBDVGWSYYEMNY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477702   

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns

US Patent
LigandPNGBDBM477702(US10889571, Example 43 | US20240101536, Example 43)
Affinity DataIC50: 0.380nMAssay Description:ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns

US Patent
LigandPNGBDBM477702(US10889571, Example 43 | US20240101536, Example 43)
Affinity DataIC50: 0.380nMAssay Description:The activity of the enzyme and compound inhibition was tested using an EZ reader microfluidic mobility shift assay (PerkinElmer, Waltham, MA). For in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent