BDBM477756 US10889571, Example 100::US20240101536, Example 100

SMILES FC(F)(Cl)Oc1ccc(NC(=O)c2cc(-c3cncnc3)c3n(CC4COC4)cnc3c2)cc1

InChI Key InChIKey=ZNTLAUBFQCFUFC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 477756   

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns

US Patent
LigandPNGBDBM477756(US10889571, Example 100 | US20240101536, Example 1...)
Affinity DataIC50: 0.460nMAssay Description:ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns

US Patent
LigandPNGBDBM477756(US10889571, Example 100 | US20240101536, Example 1...)
Affinity DataIC50: 0.460nMAssay Description:The activity of the enzyme and compound inhibition was tested using an EZ reader microfluidic mobility shift assay (PerkinElmer, Waltham, MA). For in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1 [64-515](Human)
Terns

US Patent
LigandPNGBDBM477756(US10889571, Example 100 | US20240101536, Example 1...)
Affinity DataIC50: 0.460nMAssay Description:ABL1 WT protein (64-515aa) containing an N-terminal His tag was produced by co-expression with YopH in Sf9 insect cells. Cells were harvested by cent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2025
Entry Details
US Patent