BDBM480613 2-(1-methyl-1H-pyrazol-4- yl)-5-(7-methyl-6-oxo-3- (tetrahydro-2H-pyran-4-yl)- 5,6,7,8- tetrahydroimidazo[1,5-a] pyrazin-1-yl)quinoline-3- carbonitrile::US10899769, Example 92

SMILES CN1Cc2c(nc(C3CCOCC3)n2CC1=O)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C#N

InChI Key InChIKey=XDKXSAGMLHXOPM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480613   

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 480613BDBM480613(US10899769, Example 92 | 2-(1-methyl-1H-pyrazol-4-...)
Affinity DataIC50: 63nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 480613BDBM480613(US10899769, Example 92 | 2-(1-methyl-1H-pyrazol-4-...)
Affinity DataIC50: 2.50E+4nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent