BDBM481502 US10906915, Ex. 298::[3-(3-ethyl-4-oxo-spiro[6,8- dihydro-5H-pyrazolo[4,3- c]azepine-7,4'- tetrahydropyran]-1-yl)-2,2- dimethyl-propyl] 4-cyano-2- fluoro-benzoate

SMILES CCc1nn(CC(C)(C)COC(=O)c2ccc(cc2F)C#N)c2CC3(CCOCC3)CNC(=O)c12

InChI Key InChIKey=ZTWXPRYURRDKRX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 481502   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Leo Pharma

US Patent
LigandPNGBDBM481502([3-(3-ethyl-4-oxo-spiro[6,8- dihydro-5H-pyrazolo[4...)
Affinity DataIC50: 100nMAssay Description:The human PDE4D catalytic domain (UniProt no. Q08499 [5380-L740]) was incubated with a mixture of non-labelled cAMP (cyclic adenosine monophosphate) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent