BDBM484564 US10934294, Example 85::US10934294, Example 86::US11028092, Example 86

SMILES CC(C1CCOCC1)n1nc(C#N)c2c1nc([nH]c2=O)C1CCC1c1ncc(F)cn1

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 484564   

LigandPNGBDBM484564(US10934294, Example 85 | US10934294, Example 86 | ...)
Affinity DataKi: >607nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM484564(US10934294, Example 85 | US10934294, Example 86 | ...)
Affinity DataKi: >607nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM484564(US10934294, Example 85 | US10934294, Example 86 | ...)
Affinity DataKi: >607nMAssay Description:Assays for PDE 1 through 11 were performed in parallel at room temperature in 384-well microtiter plates with an incubation volume of 20.2 μL. S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM484564(US10934294, Example 85 | US10934294, Example 86 | ...)
Affinity DataKi: >607nMAssay Description:Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent