BDBM484649 US10934297, Compound 43::US11713320, Compound 43

SMILES Cc1noc(C)c1-c1ccc2[nH]nc(C(=O)NC3CCN(CC(C)(C)F)CC3)c2c1

InChI Key InChIKey=APEPSWDGWMEHQA-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 484649   

LigandPNGBDBM484649(US10934297, Compound 43 | US11713320, Compound 43)
Affinity DataEC50:  67nMAssay Description:DYRK1A: Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

LigandPNGBDBM484649(US10934297, Compound 43 | US11713320, Compound 43)
Affinity DataEC50:  67nMAssay Description:Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Biosplice Therapeutics

US Patent
LigandPNGBDBM484649(US10934297, Compound 43 | US11713320, Compound 43)
Affinity DataEC50:  1.06E+3nMAssay Description:Each compound is dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-response curves f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Biosplice Therapeutics

US Patent
LigandPNGBDBM484649(US10934297, Compound 43 | US11713320, Compound 43)
Affinity DataEC50:  1.06E+3nMAssay Description:GSK3β: Each compound is dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:3, 11-point dose-respo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent