BDBM484849 US10934302, Example 100

SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1nc2[nH]nc(N3CCCc4ncccc34)c2nc1CO

InChI Key InChIKey=HVXNIHHDUILMQF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 484849   

TargetSH2B adapter protein 2(Human)
Relay Therapeutics

US Patent
LigandPNGBDBM484849(US10934302, Example 100)
Affinity DataIC50: 525nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent