BDBM485441 N-((1R,3S)-3-Acrylamidocyclohexyl)-5-(*R)-(4-isopropoxy-2- methylphenyl)-4-oxo-4,5-dihydro-3H-1-thia-3,5,8- triazaacenaphthylene-2-carboxamide::US10934310, Ex # 275::US11319329, Ex # 275::US12065446, Example 275

SMILES CC(C)Oc1ccc(c(C)c1)-n1c2ccnc3sc(C(=O)N[C@@H]4CCC[C@@H](C4)NC(=O)C=C)c([nH]c1=O)c23

InChI Key InChIKey=MXJANDWCCURGLZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 485441   

TargetTyrosine-protein kinase BTK(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM485441(N-((1R,3S)-3-Acrylamidocyclohexyl)-5-(*R)-(4-isopr...)
Affinity DataIC50: 1.00E+3nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK [389-659](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM485441(N-((1R,3S)-3-Acrylamidocyclohexyl)-5-(*R)-(4-isopr...)
Affinity DataIC50: 1.00E+3nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM485441(N-((1R,3S)-3-Acrylamidocyclohexyl)-5-(*R)-(4-isopr...)
Affinity DataIC50: 1.00E+3nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent