BDBM489423 US10961247, Ex. No. 38

SMILES FC(F)n1cc(Nc2nc(N[C@@H]3CCCN(C3)C(=O)C=C)c3c(Cl)c[nH]c3n2)cn1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 489423   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489423(US10961247, Ex. No. 38)
Affinity DataIC50:  4.30nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489423(US10961247, Ex. No. 38)
Affinity DataIC50:  0.100nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent