BDBM489535 US10961247, Ex. No. 142

SMILES CCC#CC(=O)N1CCC[C@H](C1)Nc1nc(Nc2ccc(cc2)N2CCN(C)CC2)nc2[nH]cc(Cl)c12

InChI Key InChIKey=JHIJMWIOWOIHKT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 489535   

TargetTyrosine-protein kinase JAK3(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489535(US10961247, Ex. No. 142)
Affinity DataIC50: 22.4nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489535(US10961247, Ex. No. 142)
Affinity DataIC50: 210nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent