BDBM490277 US10968215, Compound 154

SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(-c3ccn[nH]3)ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C

InChI Key InChIKey=JLFCUKAPURTRAC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 490277   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 490277BDBM490277(US10968215, Compound 154)
Affinity DataIC50: 100nMAssay Description:EZH2 wild type: Experimental method: avdin of a final concentration of 100 nM was used to coat 96-well plate at 10 μL/well, placed in a wet box ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 490277BDBM490277(US10968215, Compound 154)
Affinity DataIC50: 100nMAssay Description:EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 490277BDBM490277(US10968215, Compound 154)
Affinity DataIC50: 100nMAssay Description:Inhibition of wild-type EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Shanghai Haihe Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 490277BDBM490277(US10968215, Compound 154)
Affinity DataIC50: 100nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed