BDBM490321 (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-methyl-1-(2-methylpyrimidin-5-yl)-5-(1-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)ethyl)indolizine-7-formamide ::US10968215, Compound 198

SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(-c3ccnc4c3CCN4)ccn2c([C@@H](C)N2CCN(CC(F)(F)F)CC2)c1C

InChI Key InChIKey=GUTYCSPKDSWGEZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 490321   

LigandChemical structure of BindingDB Monomer ID 490321BDBM490321(US10968215, Compound 198 | (R)-N-((4-methoxy-6-met...)
Affinity DataIC50: 100nMAssay Description:EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent