BDBM490601 2-{[(2S)-1-(dimethylamino)propan-2-yl]oxy}-5-fluoro-N-(4-fluoro-2-methylphenyl)-4-(3-oxo-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)benzamide::US10968216, Example 269

SMILES C[C@@H](CN(C)C)Oc1cc(c(F)cc1C(=O)Nc1ccc(F)cc1C)-n1nc2CCCCn2c1=O

InChI Key InChIKey=AUOBSWNVQNQTEE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 490601   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
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US Patent
LigandPNGBDBM490601(US10968216, Example 269 | 2-{[(2S)-1-(dimethylamin...)
Affinity DataIC50: 30nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
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Date in BDB:
10/9/2021
Entry Details
US Patent