BDBM490630 US10968216, Example 298::rac-2-{[1-aminopropan-2-yl]oxy}-N-(2-chloro-6-fluorophenyl)-5-fluoro-4-(3-oxo-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)benzamide, salt with hydrochloric acid

SMILES C[C@H](CN)Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1Cl)-n1nc2CCCCn2c1=O

InChI Key InChIKey=NTZOQPXHCDCMHY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 490630   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
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US Patent
LigandPNGBDBM490630(US10968216, Example 298 | rac-2-{[1-aminopropan-2-...)
Affinity DataIC50: 1.60E+3nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
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Date in BDB:
10/9/2021
Entry Details
US Patent