BDBM491785 4-Chloro-1-ethyl-5-(4-methoxy-6-((2-(trifluoromethyl)cyclobutyl)amino)pyridin-3-yl)-N-(((1r,4r)-4-(methylsulfonyl)cyclohexyl)methyl)-1H-pyrazole-3-carboxamide, Fraction A::US10975057, Example 71::US10975057, Example 72

SMILES CCn1nc(C(=O)NC[C@H]2CC[C@@H](CC2)S(C)(=O)=O)c(Cl)c1-c1cnc(NC2CCC2C(F)(F)F)cc1OC

InChI Key InChIKey=YBNBAGWVEIUCMS-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 491785   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM491785(US10975057, Example 71 | 4-Chloro-1-ethyl-5-(4-met...)
Affinity DataKd:  24nMAssay Description:For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM491785(US10975057, Example 71 | 4-Chloro-1-ethyl-5-(4-met...)
Affinity DataKd:  73nMAssay Description:For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent