BDBM492157 5-(4-(Difluoromethyl)-6-(((R)-3,3-dimethylbutan-2-yl)amino)pyridin-3-yl)-N-(2-hydroxy-2-methylpropyl)-4-((S)-2-methylpyrrolidine-1-carbonyl)thiazole-2-carboxamide::US10975068, Example 298

SMILES C[C@@H](Nc1cc(C(F)F)c(cn1)-c1sc(nc1C(=O)N1CCC[C@@H]1C)C(=O)NCC(C)(C)O)C(C)(C)C

InChI Key InChIKey=QYWJKVPONVAFPG-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 492157   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM492157(5-(4-(Difluoromethyl)-6-(((R)-3,3-dimethylbutan-2-...)
Affinity DataKd:  3.40nMAssay Description:1,8-ANS (Invitrogen) was used as a fluorescent dye. Protein and compound solutions are dispensed into black 384-well polypropylene PCR microplates (A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
US Patent