BDBM493019 US10981906, Example 118::methyl 4-(((3R,4R)-1-(2-cyanoacetyl)-4- methylpiperidin-3-yl)amino)-1H-pyrrolo[2,3- b]pyridine-5-carboxylate

SMILES COC(=O)c1cnc2[nH]ccc2c1N[C@H]1CN(CC[C@H]1C)C(=O)CC#N

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493019   

TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))
Aclaris Therapeutics

US Patent
LigandPNGBDBM493019(US10981906, Example 118 | methyl 4-(((3R,4R)-1-(2-...)
Affinity DataIC50:  55nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aclaris Therapeutics

US Patent
LigandPNGBDBM493019(US10981906, Example 118 | methyl 4-(((3R,4R)-1-(2-...)
Affinity DataIC50:  550nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent