BDBM495171 US10995089, Example 6::US11708364, Example 6

SMILES Clc1ccc(s1)-c1cnc2[nH]cc(-c3ccn(Cc4cccc(Cl)c4)c(=O)c3)c2c1

InChI Key InChIKey=OIFUBRLTEDUXQP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 495171   

TargetMitogen-activated protein kinase 1(Human)
Agv Discovery

US Patent
LigandPNGBDBM495171(US10995089, Example 6 | US11708364, Example 6)
Affinity DataIC50: 37.5nMAssay Description:To assess compounds capacity to inhibit ERK2 enzymatic activity, Z′-Lyte biochemical assay from Life technologies was used according to manufac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Agv Discovery

US Patent
LigandPNGBDBM495171(US10995089, Example 6 | US11708364, Example 6)
Affinity DataIC50: 400nMAssay Description:To assess compounds capacity to inhibit ERK2 enzymatic activity, Z′-Lyte biochemical assay from Life technologies was used according to manufac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent