BDBM497074 US11001561, Compound 63::US11001561, Compound 63a::US11104675, Example 10b::US11702392, Compound 63

SMILES Cc1c(N2CCC3(CC2)CO[C@@H](C)[C@H]3N)nc(C)n(-c2cccc(Cl)c2Cl)c1=O

InChI Key InChIKey=ABKATOFAZUIEJX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 497074   

LigandChemical structure of BindingDB Monomer ID 497074BDBM497074(US11104675, Example 10b | US11001561, Compound 63 ...)
Affinity DataIC50: 28nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497074BDBM497074(US11104675, Example 10b | US11001561, Compound 63 ...)
Affinity DataIC50: 39nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497074BDBM497074(US11104675, Example 10b | US11001561, Compound 63 ...)
Affinity DataIC50: 39nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 497074BDBM497074(US11104675, Example 10b | US11001561, Compound 63 ...)
Affinity DataIC50: 2.58E+3nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 497074BDBM497074(US11104675, Example 10b | US11001561, Compound 63 ...)
Affinity DataIC50: 6.00E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
US Patent