BDBM497783 (3S)-3-[1-[4-[(1S,8R)-5-(2,6- difluorophenyl)-11,11-dimethyl-3,4- diazatricyclo[6.2.1.02,7]undeca-2,4,6- trien-1-yl]pyrimidin-2-yl]-1,2,4-triazol-3- yl]thiolane 1,1-dioxide::US11008312, Example 269

SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1ccnc(n1)-n1cnc(n1)[C@@H]1CCS(=O)(=O)C1

InChI Key InChIKey=CZEBZCBEYWNUSQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 497783   

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM497783((3S)-3-[1-[4-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 28nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
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