BDBM497789 (1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[2-[2-(methylsulfonylmethyl)- 1,2,4-triazol-3-yl]pyrimidin-4-yl]-3,4- diazatricyclo[6.2.1.02,7]undeca-2(7),3,5- triene::US11008312, Example 275

SMILES CC1(C)[C@H]2CC[C@@]1(c1nnc(cc21)-c1c(F)cccc1F)c1ccnc(n1)-c1ncnn1CS(C)(=O)=O

InChI Key InChIKey=FIOSFYLVJMBMMO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 497789   

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM497789((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...)
Affinity DataIC50: 61nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent