BDBM498412 (1R,3S)-3-(3-{[(6- methylpyridin-3- yl)acetyl]amino}-1H-pyrazol- 5-yl)cyclopentyl ethyl(methyl)carbamate::US11014911, Example 237::US11718603, Example 237

SMILES CCN(C)C(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccc(C)nc2)n[nH]1

InChI Key InChIKey=GLEIZJBQDQWBKF-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498412   

LigandPNGBDBM498412((1R,3S)-3-(3-{[(6- methylpyridin-3- yl)acetyl]am...)
Affinity DataKi:  0.640nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

LigandPNGBDBM498412((1R,3S)-3-(3-{[(6- methylpyridin-3- yl)acetyl]am...)
Affinity DataKi:  0.640nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498412((1R,3S)-3-(3-{[(6- methylpyridin-3- yl)acetyl]am...)
Affinity DataKi:  5.23nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498412((1R,3S)-3-(3-{[(6- methylpyridin-3- yl)acetyl]am...)
Affinity DataKi:  5.23nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent