BDBM498416 (1S,3R)-3-(3-{[(2- methoxypyridin-4-yl) acetyl]amino}-1H-pyrazol- 5-yl)cyclopentyl ethyl(methyl)carbamate::US11014911, Example 241::US11718603, Example 241

SMILES CCN(C)C(=O)O[C@H]1CC[C@H](C1)c1cc(NC(=O)Cc2ccnc(OC)c2)n[nH]1

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498416   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498416((1S,3R)-3-(3-{[(2- methoxypyridin-4-yl) acetyl]a...)
Affinity DataKi:  1.04nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498416((1S,3R)-3-(3-{[(2- methoxypyridin-4-yl) acetyl]a...)
Affinity DataKi:  1.04nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498416((1S,3R)-3-(3-{[(2- methoxypyridin-4-yl) acetyl]a...)
Affinity DataKi:  13.4nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498416((1S,3R)-3-(3-{[(2- methoxypyridin-4-yl) acetyl]a...)
Affinity DataKi:  13.4nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent