BDBM498422 (1R,3S)-3-(3-{[(6- methylpyridin-3-yl) acetyl]amino}-1H-pyrazol-5- yl)cyclopentyl (2,2- difluoroethyl)carbamate::US11014911, Example 247::US11718603, Example 247

SMILES Cc1ccc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NCC(F)F)cn1

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498422   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498422((1R,3S)-3-(3-{[(6- methylpyridin-3-yl) acetyl]am...)
Affinity DataKi:  1.36nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498422((1R,3S)-3-(3-{[(6- methylpyridin-3-yl) acetyl]am...)
Affinity DataKi:  1.36nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498422((1R,3S)-3-(3-{[(6- methylpyridin-3-yl) acetyl]am...)
Affinity DataKi:  12.2nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498422((1R,3S)-3-(3-{[(6- methylpyridin-3-yl) acetyl]am...)
Affinity DataKi:  12.2nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent