BDBM498450 (1R,3S)-3-(3-{[(4- methoxyphenyl)acetyl]amino}- 1H-pyrazol-5-yl)cyclopentyl propan-2-ylcarbamate::US11014911, Example 275::US11718603, Example 275

SMILES CC(C)NC(=O)O[C@@H]1CC[C@@H](C1)c2cc(n[nH]2)NC(=O)Cc3ccc(cc3)OC

InChI Key InChIKey=OFSZDCXMNSCJLL-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498450   

LigandPNGBDBM498450((1R,3S)-3-(3-{[(4- methoxyphenyl)acetyl]amino}- ...)
Affinity DataKi:  0.490nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

LigandPNGBDBM498450((1R,3S)-3-(3-{[(4- methoxyphenyl)acetyl]amino}- ...)
Affinity DataKi:  0.490nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498450((1R,3S)-3-(3-{[(4- methoxyphenyl)acetyl]amino}- ...)
Affinity DataKi:  53.1nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498450((1R,3S)-3-(3-{[(4- methoxyphenyl)acetyl]amino}- ...)
Affinity DataKi:  53.1nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
Go to US Patent