BDBM498573 (1R,3S)-3-(3-{[(6- methylpyridin-3- yl)acetyl]amino}-1H-pyrazol-5- yl)cyclopentyl [(2$#958;)-1,1,1- trifluorobutan-2-yl]carbamate - Isomer A::US11014911, Example 398::US11014911, Example 399::US11718603, Example 399

SMILES CCC(NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccc(C)nc2)n[nH]1)C(F)(F)F

InChI Key InChIKey=ZBKYUHYCKHIUOK-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 498573   

LigandPNGBDBM498573(US11014911, Example 398 | US11014911, Example 399 ...)
Affinity DataKi:  0.470nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent

LigandPNGBDBM498573(US11014911, Example 398 | US11014911, Example 399 ...)
Affinity DataKi:  0.470nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

LigandPNGBDBM498573(US11014911, Example 398 | US11014911, Example 399 ...)
Affinity DataKi:  0.650nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent

LigandPNGBDBM498573(US11014911, Example 398 | US11014911, Example 399 ...)
Affinity DataKi:  0.650nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498573(US11014911, Example 398 | US11014911, Example 399 ...)
Affinity DataKi:  44.1nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498573(US11014911, Example 398 | US11014911, Example 399 ...)
Affinity DataKi:  44.1nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498573(US11014911, Example 398 | US11014911, Example 399 ...)
Affinity DataKi:  68.8nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandPNGBDBM498573(US11014911, Example 398 | US11014911, Example 399 ...)
Affinity DataKi:  68.8nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent